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Compellis Pharmaceuticals, Inc.

Calcium Channel Blocker for Weight Reduction Print E-mail

Mechanism of Action

Olfactory input affects food intake in several important ways, influencing the onset of eating, the choice of food eaten at a meal, and the cessation of eating at the end of a meal. In addition to decreasing caloric intake by reducing olfactory function, an olfactory block will modify mechanisms involved in initiating and terminating meals.

Before a meal, food odors and flavor increase the appetite or cravings, especially in restrained eaters or chronic dieters. At the end of a meal, sensory-mediated satiety plays a role in stopping eating: habituation to the smell or flavor of a food during the course of the meal results in a decrease in the pleasantness of that food and consequently the termination of the meal.

olfactory_nerveOlfactory Perception: Novel weight loss target

  • Volatile compounds pass over the olfactory epithelium
  • Odorants stimulate a nerve impulse into the brain
  • Connection is direct to the brain

 

 

 

olfactory_bulb

Compellis drug blocks calcium channel activity:

  • Major odorant signal transduction pathways